Leyla Elif Sade Akdoğan Prof. M.D



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1981- 1989        High School                           French Lycée Saint Benoit, Istanbul

1989-1995         Medical School                      Hacettepe Univeristy, Medical School Ankara,

1995-2001         Cardiology Residency                       Hacettepe Univeristy, Medical SchoolAnkara,

July, 1995          Medical Licensure                  Hacettepe University, Medical SchoolAnkara,

July 2001           Cardiology Licensure             Hacettepe University, Medical SchoolAnkara, 2001-2002  Echo Research Fellowship         University of Pittsburgh Medical Center, PA,    


2003-                  Staff Cardiologist                  Baskent University, Medical School, Ankara                                                            2006-2013         Assoc. Prof. of Cardiology    Baskent University, Medical School, Ankara

2013-                  Professor of Cardiology         Baskent University, Medical School, Ankara


Other Academic Appointments:

Invited Faculty as Opponent of PhD Thesis Defense, Oslo University, Norway, October 2016

Visiting Professor for Echo Guided Interventional Procedures (Mitraclip) University of Rennes, France, June-July 2018


Educational/Scientific Programs Directed:


Program Director “Advanced Echocardiography Course” sponsored by Baskent University, Ankara 15-16 June, 2015

Program Director “Echo Teaching for the Young Cardiologists of the European Association of Cardiovascular Imaging”, Antalya, October 24th, 2016

Host of Live DICE Webinar on Clinical Use of Strain Imaging, sponsored by the European Association of Cardiovascular Imaging, Heart House, Nice, October 16, 2016.

Program Director “3D Imaging Course of Turkish Society of Cardiology, March 3, 2017, Cyprus.

Program Director “Teaching Course: Deep Dive in 3D” in Updates in Cardiology and Cardiovascular Surgery Annual Meeting, 24 March 2017, Izmir

Program Director “Advanced Echocardiography on Cardiomyopathies” in Updates in Cardiology and Cardiovascular Surgery Annual Meeting, 6 April 2018, Antalya.

Program Director “3D and Strain hands-on teaching Course of Turkish Society of Cardiology” 12 May 2018, Ankara.

Program Director “EACVI Teaching Course for Heart Imagers of Tomorrowé, 20 October 2018, Antalya



July, 2008                                             European Cardiologist Diploma

January, 2005                                       European Association of Echocardiography                       

TTE Accreditation (renewed in 2016)

December,1996                        United State Medical Licensing Examination

(USMLE) Certification                    



FOREIGN LANGUAGES          Fluent in French                                                                     

                                                           Fluent in English



Teaching Responsabilities

2003-                                      Teaching of third, fourth, fifth and sixth year medical students,

                                               Baskent University School of Medicine


2003-                                      Teaching of Cardiology Fellowship Program, Baskent

                                               University School of Medicine


2007-                                      Mentor, Senior Cardiology Fellows’ theses, Baskent University

                                               Schoool of Medicine


1)  Thrombocyte GGT activity in patients with acute coronary syndrome: relationship with clinical outcome, Koray Demirtaş MD, (2007)

2)  Impact of cardiac resynchronization therapy on left and right ventricular functions in serial follow-up Özlem Demir MD, (2008).

3)  Assessment of coronary microvascularfunctions in patients with migraine, Gamze Aslan MD (2009).

4)  Assessment of coronary flow reserve in patients with end-stage chronic liver disease, Saadet Demirtaş MD, (2009).

5)  Effects of Paclitaxel and Carboplatin combination on mechanical myocardial and microvascular functions: a transthoracic Doppler echocardiography and two-dimensional strain imaging study, Cihan Altın MD, (2010).

6) Invasive versus noninvasive method to optimize pacemakers in patients receiving cardiac resynchronization therapy, Hafize Cörüt MD,(2014)

7) Comparison of different echocardiographic approaches to predict the impact of pulmonary hypertension n RV function, Aslı Bircan MD, (2014).

8) Concomittant use of echocardiographic strain analysis and treadmill stress testing to predict coronary rtery disease, Hatice Kozan MD, (2016)




Major Research Interest

Echocardiography, strain, 3Dimaging,myocardial mechanics, heart failure, transplantation,resynchronization therapy.


Assignments in Professional Societies

European Association of Cardiovascular Imaging (EACVI) – Chair of Membership Committee 2016-

EACVI Education Committee Member 2016-

EACVI Echo Nucleus Member 2016-

EACVI Board Member 2014-

EACVI Member since 2004.

Board member, Working Group on Valvular Heart Disease, Turkish Society of Cardiology  2007-2011

Board member, Working Group on Cardiovascular Imaging, Turkish Society of Cardiology. 2011-

Chair of the Working Group on Cardiovascular Imaging, Turkish Society of Cardiology 2013-2015.

Board member, Board of Accreditation of the Turkish Society of Cardiology.2012 –

Fellow of the European Society of Cardiology, 2008-


Editorial Board Member

European Journal of Cardiology Cardiovascular Imaging

Journal of the American ociety of Echocardiography

Anatolian Journal of Cardiology (Associate Editor)

Archives of the Turkish Society of Cardiology


Manuscript Reviewer (within the last 2 yers)

European Heart Journal

Journal of the American College of Cardiology

Journal of the American College of Cardiology- Cardiovascular Imaging

European Heart Journal Cardiovascular Imaging

Journal of the American Society of Echocardiography

International Journal of Cardiovascular Imaging

International Journal of Cardiology

American Journal of Cardiology


Journal of Cardiac Failure

Anatolian Journal of Cardiology

Archives of Turkish Society of Cardiology


Abstract Reviewer (regular since)

2006-                  International Congress of Cardiology and Cardiovascular Updates

2007-                   Turkish Society of Cardiology Congress, Scientific Sessions

2012-                   European Society of Cardiology Congress, Scientific Sessions

2010-                   EuroEcho Imaging Congress, Scientific Sessions



Other Activities in Professional Bodies

Expert Consensus Document Co-Author in European Association of Cardiovascular Imaging (EACVI) documents

2017    Multimodality imaging in restrictive cardiomyopathies.Eur Heart J Cardiovasc Imaging. 2017;18:1090-1121.

2017    Appropriateness criteria for the use of transthoracic echocardiography in adults.  Eur Heart J Cardiovasc Imaging. 2017,18:1191-1204

2017    Standardization of adult transthoracic echocardiography reporting in agreement with recent chamber quantification, diastolic function, and heart valve disease recommendations.Eur Heart J Cardiovasc Imaging. 2017;18:1301-1310.


Expert Consensus Document Co-Author in American Society of Echocardiography (ASE) Documents

2018    Writing Group on Rheumathic Heart Diseases (in press)


Guideline and Consensus Document Reviewer

2014    Guideline Reviewer for 2014 ESC guidelines on the diagnosis and management of

acutepulmonary embolism.

2016    Comprehensive multi-modality imaging approachin arrhythmogenic cardiomyopathy

2018    Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography.Eur Heart J Cardiovasc Imaging. 2018;19:591-600.



2016    EACVI Reasearch Grant reviewer



Invited Lectures (International Congresses):


Lectures at American Society of Echocardiography Annual Scientific Sessions, June 2016, 2017,2018

Lectures at Euroecho Imaging 2008, 2010, 2013, 2014, 2015, 2016, 2017, 2018

Lectures at European Cardiology Congresses, 2009, 2014, 2015, 2016, 2017

Lectures at Echocardiography Today and Tomorrow, Austria, 2015, 2017

Lecture at Congress of Romanian Cardiac Society, May 2017

Lecture at EACVI Teaching Course, April 2017, Bulgaria

Lectures at World Congress of Echocardiography, 2004, 2016, 2018

Lectures at EACVI Teaching Courses, April 2014, 2017 Bulgaria

Lecture at Annual Congress of Polish Socaiety of Cardiology, October 2008, Poland.

Lectures at lnternational Congress of Updates of Cardiology and Cardiovascular Surgery 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018



Selected Publications in Peer Reviewed Journals


  1. Sade LE, HazirolanT, Kozan H, Ozdemir H, Hayran M, Eroglu S, Pirat B,Sezgin S, Muderrisoglu H.T1 Mapping by Cardiac Magnetic Resonance and Multidimensional Speckle Tracking Strain by Echocardiography for the Detection of Acute Cellular Rejection in Cardiac Allograft Recipients JACC Imaging (Under review)
  2. Sade LE, Kozan H, Eroglu S, Pirat B, Aydinalp A, Sezgin A, Muderrisoglu H.

Three-Dimensional Right Ventricular Strain Versus Volume Quantification in Heart Transplant Recipients in Relation to Pulmonary Artery Pressure.Exp Clin Transplant. 2017;15(Suppl 1):231-235.

  1. Sade LESpeckle tracking strain imaging: Practical approach for application.

Turk Kardiyol Dern Ars. 2017;45:197-205.

  1. Sade LE, Atar I, Özin B, Yüce D, Müderrisoğlu H. Determinants of New-Onset Atrial Fibrillation in Patients Receiving CRT: Mechanistic Insights From Speckle Tracking Imaging Sade LE. JACC Cardiovasc Imaging 2016;9:99-111.
  2. Sade LE. Vascular Function Tests in Women With no Obstructive CAD: A Few Pieces of the Puzzle. JACC Cardiovasc Imaging 2016;9:418-20.
  3. Sade LE, Saba S, Marek JJ, Onishi T, Schwartzman D, Adelstein EC, Soman P, Gorcsan J 3rd The association of left ventricular lead position related to regional scar by speckle-tracking echocardiography with clinical outcomes in patients receiving cardiac resynchronization therapy.J Am Soc Echocardiogr. 2014;27:648-56.
  4. Sade LE, Eroğlu S, Yüce D, Bircan A, Pirat B, Sezgin A, Aydınalp A, Müderrisoğlu H.Follow-up of heart transplant recipients with serial echocardiographic coronary flow reserve and dobutamine stress echocardiography to detect cardiac allograft vasculopathy.J Am Soc Echocardiogr. 2014;27:531-9.
  5. Sade LE, Özin B, Atar I, Demir Ö, Demirtaş S, Müderrisoğlu H.Right ventricular function is a determinant of long-term survival after cardiac resynchronization therapy.J Am Soc Echocardiogr. 2013;26:706-13.
  6. Sade LE. Echocardiographic longitudinal, radial, circumferential and rotational synchronization disturbance in predicting response to cardiac resynchronization therapy. Anatolian J Cardiol. 2010;10:81-7.
  7. Sade LE, Gülmez O, Ozyer U, Ozgül E, Ağildere M, Müderrisoğlu H.

Tissue Doppler study of the right ventricle with a multisegmental approach: comparison with cardiac magnetic resonance imaging. J Am Soc Echocardiogr 2009;22:361-8.

  1. Sade LE, Demir O, Atar I, Müderrisoğlu H, Ozin B. Effect of right ventricular pacing lead on left ventricular dyssynchrony in patients receiving cardiac resynchronization therapy.  Am J Cardiol 2009;103:695-700.
  2. Sade LE, Eroglu S, Bozbaş H, Ozbiçer S, Hayran M, Haberal A, Müderrisoğlu H.Relation between epicardial fat thickness and coronary flow reserve in women with chest pain and angiographically normal coronary arteries.  Atherosclerosis 2009;204:580-5.
  3. Sade LE, Ozin B, Ulus T, Açikel S, Pirat B, Bilgi M, Uluçam M, Müderrisoğlu H.Right ventricular contractile reserve in mitral stenosis: implications on hemodynamic burden and clinical outcome.  Int J Cardiol 2009;135:193-201.
  4. Sade LE. Functional mitral regurgitation. Anatolian J Cardiol. 2009;9 Suppl 1:3-9.
  5. Sade LE, Demir O, Atar I, Müderrisoglu H, Ozin B. Effect of mechanical dyssynchrony and cardiac resynchronization therapy on left ventricular rotational mechanics. Am J Cardiol 2008;101:1163-9.
  6. Sade LE, Sezgin A, Eroğlu S, Bozbaş H, Uluçam M, Müderrisoğlu H.Dobutamine stress echocardiography in the assessment of cardiac allograft vasculopathy in asymptomatic recipients. Transplant Proc. 2008;40:267-70.
  7. Sade LE, Gulmez O, Eroglu S, Sezgin A, Muderrisoglu H. Noninvasive estimation of right ventricular filling pressure by ratio of early tricuspid inflow to annular diastolic velocity in patients with and without recent cardiac surgery. J Am Soc Echocardiogr 2007;20:982-8.
  8. Sade LE, Sezgin A, Uluçam M, Taymaz S, Simşek V, Tayfun E, Tokel K, Aşlamaci S, Müderrisoğlu H.Evaluation of the potential role of echocardiography in the detection of allograft rejection in heart transplant recipients.Transplant Proc. 2006;38:636-8.
  9. Sade LE, Gorcsan J 3rd, Severyn DA, Edelman K, Katz WE. Usefulness of angle corrected tissue Doppler to assess segmental left ventricular function during dobutamine stress echocardiography in patients with and without coronary artery disease. Am J Cardiol 2005 ;96:141-7.
  10. Sade LE, Kanzaki H, Severyn D, Dohi K, Gorcsan J 3rd. Quantification of radial mechanical dyssynchrony in patients with left bundle branch block and idiopathic dilated cardiomyopathy without conduction delay by tissue displacement imaging. Am J Cardiol 2004;94:514-8.
  11. Sade LE, Severyn DA, Kanzaki H, Dohi K, Gorcsan J 3rd. Second-generation tissue Doppler with angle-corrected color-coded wall displacement for quantitative assessment of regional left ventricular function. Am J Cardiol. 2003;92(5):554-60.
  12. Sade E, Aytemir K, Oto A, Nazli N, Ozmen F, Ozkutlu H, Tokgözoglu L, Aksöyek S, Ovünç K, Kabakçi G, Ozer N, Kes S. Assessment of heart rate turbulence in the acute phase of myocardial infarction for long-term prognosis. Pacing Clin Electrophysiol. 2003;26(2 Pt 1):544-50.

Co-Author Multicenter Registry Design of European Association of Cardiovascular Imaging

  1. Donal E, Delgado V, Magne J, Bucciarelli-Ducci C, Leclercq C, Cosyns B, Sitges M, Edvardsen T, Sade E, Stankovic I, Agricola E, Galderisi M, Lancellotti P, Hernandez A, Plein S, Muraru D, Schwammenthal E, Hindricks G, Popescu BA, Habib G.Rational and design of EuroCRT: an international observational study on multi-modality imaging and cardiac resynchronization therapy. Eur Heart J Cardiovasc Imaging. 18(10):1120-1127.



  1. Galderisi M, Donal E, Magne J, Lo Iudice F, Agricola E, Sade LE, Cameli M, Schwammenthal E, Cardim N, Cosyns B,Hagendorff A, Neskovic A, Zamorano JL, Lancellotti P, Habib G, Edvardsen T Popescu BS.Rationale and Design of the EACVI AFib Echo Registry for assessing relationships of echocardiographic parameters with clinical thromboembolic and bleeding risk profile in patients with non valvular atrial fibrillationEur Heart J Cardiovasc Imaging. [Submitted]


Textbook Chapters

Baumgartner H, Orwat S, Sade E, Bermejo X. Heart Valve Disease (aortic valve disease): Aortic Stenosis. The EACVI Textbook of Echocardiography. Eds. Lancellottı P, Zamorano JL, Habib G, Badano L . 2nd Edition. Oxford University Press, United Kingdom. 2017,pp.234-250.


Sade LE, Picano E. Stress echocardiography after cardiac transplantation. Stress Echocardiography. Ed. Picano E. 6th Edition. Springer, Pisa, Italy. 2015, pp.569-584.


Sade, E. ve A. Oto. “Post-extrasystolic heart rate turbulence as a risk predictor: What are the perspectives and limitations?”, Cardiac Arrhythmias, ed. A. Raviele, p228-236, Springer-Verlag, Milan, 2002.